Pesticide exposure increases the incidence of low birth weight in agricultural areas

Authors

  • Fajar Dini Hariyanti Faculty of Nursing, Universitas Jember, Indonesia
  • Gisca Yuan Sausan Faculty of Nursing, Universitas Jember, Indonesia
  • Rianti Yulia Kusuma Ayu Faculty of Nursing, Universitas Jember, Indonesia
  • Enggal Hadi Kurniyawan Faculty of Nursing, University of Jember
  • Alfid Tri Afandi Faculty of Nursing, Universitas Jember, Indonesia
  • Dicky Endrian Kurniawan Faculty of Nursing, Universitas Jember, Indonesia
  • Kholid Rosyidi Muhammad Nur Faculty of Nursing, University of Jember

Keywords:

Pesticide, Low birth weight, Agriculture

Abstract

The widespread use of pesticides in agriculture and households poses serious health risks, especially in low-income countries with weak regulatory enforcement. Pregnant women are particularly vulnerable, as prenatal pesticide exposure is linked to low birth weight (LBW) through hormonal and neurotoxic effects. Socioeconomic challenges and proximity to agricultural areas further increase these risks, making it essential to address this issue to improve maternal and neonatal health in farming communities. This study analyzes the incidence of LBW according to levels of prenatal pesticide exposure among pregnant women in agricultural communities by examining environmental exposure patterns and birth outcome data. A literature review was conducted for 2019–2025 using PubMed, ScienceDirect, SSRN, Wiley Online Library, and ProQuest, and from an initial pool of 142,730 records, filters for research articles, full-text availability, and topic relevance yielded 14 studies for final analysis. Across the 14 studies, prenatal pesticide exposure was consistently associated with an increased risk of LBW and fetal growth restriction. Key factors influencing this risk included low socioeconomic status, pesticide type (organophosphates, fumigants), and timing of exposure—particularly during the second trimester. Living near agricultural areas also correlated with higher exposure levels, which may impair placental function, disrupt hormonal balance, and interfere with fetal tissue development. Some studies additionally reported long-term developmental problems. Prenatal pesticide exposure significantly increases the risk of LBW. Reducing maternal pesticide exposure and strengthening protective health interventions are crucial to improving agricultural communities' birth outcomes.

References

Ahmad, M. F., Ahmad, F. A., Alsayegh, A. A., Zeyaullah, M., AlShahrani, A. M., Muzammil, K., Saati, A. A., Wahab, S., Elbendary, E. Y., Kambal, N., Abdelrahman, M. H., & Hussain, S. (2024). Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures. Heliyon, 10(7), e29128. https://doi.org/10.1016/j.heliyon.2024.e29128

Arsyi, M., Besral, B., Herdayati, M., & Phalkey, R. (2022). Antenatal Care Services and Incidence of Low Birth Weight: A Comparison of Demographic and Health Surveys in 4 ASEAN Countries. Journal of Preventive Medicine and Public Health, 55(6), 559–567. https://doi.org/10.3961/jpmph.22.316

Calzada, J., Gisbert, M., & Moscoso, B. (2023). The Hidden Cost of Bananas: The Effects of Pesticides on Newborns’ Health. Journal of the Association of Environmental and Resource Economists, 10(6), 1623–1663. https://doi.org/10.1086/725349

Cecchi, A., Alvarez, G., Quidel, N., Bertone, M. C., Anderle, S., Sabino, G., Magnarelli, G. G., & Rovedatti, M. G. (2021). Residential proximity to pesticide applications in Argentine Patagonia: impact on pregnancy and newborn parameters. Environmental Science and Pollution Research, 28(40), 56565–56579. https://doi.org/10.1007/s11356-021-14574-2

Damiri, D., Bahri, D. A., Yanti, N. I., Kurniyawan, E. H., Kurniawan, D. E., Nur, K. R. M., & Afandi, A. T. (2025). Analysis Of Pesticide Exposure Can Increase The Risk Of Low Birth Weight Incidence In Agricultural Areas. International Journal of Midwifery and Health Sciences, 3(1), 20–36.

Herawati, S., & Tridiyawati, F. (2023). Risk Factor Analysis Of Low Birth Weight Events (Lbw) At Kartika Husada Hospital. International Journal of Health and Pharmaceutical (IJHP), 3(4), 646–651. https://doi.org/10.51601/ijhp.v3i4.220

Herwanto, E. S., Hudiyanto, P. S., & Muhammad, I. (2024). Factors of Maternal Influence on Low Birth Weight. Asian Journal of Health Research, 3(1), 5–10. https://doi.org/10.55561/ajhr.v3i1.144

Hu, J. M. Y., Arbuckle, T. E., Janssen, P. A., Lanphear, B. P., Alampi, J. D., Braun, J. M., MacFarlane, A. J., Chen, A., & McCandless, L. C. (2024). Gestational exposure to organochlorine compounds and metals and infant birth weight: effect modification by maternal hardships. Environmental Health: A Global Access Science Source, 23(1), 1–18. https://doi.org/10.1186/s12940-024-01095-x

Kumar, S. N., Vaibhav, K., Bastia, B., Singh, V., Ahluwalia, M., Agrawal, U., Borgohain, D., Raisuddin, S., & Jain, A. K. (2021). Occupational exposure to pesticides in female tea garden workers and adverse birth outcomes. Journal of Biochemical and Molecular Toxicology, 35(3). https://doi.org/10.1002/jbt.22677

Kurniyawan, E. H., Afandi, A. T., & Kurniawan, D. E. (2023). Pesticide Exposure During Pregnancy Increases the Incidence of Autism. Jurnal Bidan Mandiri, 1(2), 47-59. https://doi.org/10.33761/jbm.v1i2.1262

Kurniyawan, E., Iswatiningtyas, N., Cahyarani, F., Sholihah, N., Wati, D., Sapitri, R., & Afandi, A. (2024). Overview Of Reproductive Health In Women In Agricultural Areas Due To Exposure To Pesticides. Malang Journal Of Midwifery (MAJORY), 6(1), 1-13. doi:10.31290/majory.v6i1.4131

Lin, S., Li, J., Wu, J., Yang, F., Pei, L., & Shang, X. (2022). Interactive effects of maternal exposure to chemical fertilizer and socioeconomic status on the risk of low birth weight. BMC Public Health, 22(1), 1–11. https://doi.org/10.1186/s12889-022-13604-z

López-Benítez, A., Guevara-Lara, A., Domínguez-Crespo, M. A., Andraca-Adame, J. A., & Torres-Huerta, A. M. (2024). Concentrations of Organochlorine, Organophosphorus, and Pyrethroid Pesticides in Rivers Worldwide (2014–2024): A Review. Sustainability (Switzerland), 16(18). https://doi.org/10.3390/su16188066

Matsuki, T., Ebara, T., Tamada, H., Ito, Y., Yamada, Y., Kano, H., Kurihara, T., Sato, H., Kato, S., Saitoh, S., Sugiura-Ogasawara, M., & Kamijima, M. (2020). Association between prenatal exposure to household pesticides and neonatal weight and length growth in the japan environment and children’s study. International Journal of Environmental Research and Public Health, 17(12), 1–19. https://doi.org/10.3390/ijerph17124608

Pathak, V. M., Verma, V. K., Rawat, B. S., Kaur, B., Babu, N., Sharma, A., Dewali, S., Yadav, M., Kumari, R., Singh, S., Mohapatra, A., Pandey, V., Rana, N., & Cunill, J. M. (2022). Current status of pesticide effects on environment, human health and it’s eco-friendly management as bioremediation: A comprehensive review. Frontiers in Microbiology, 13(August), 1–29. https://doi.org/10.3389/fmicb.2022.962619

Putri, S. A., Setyowati, P. S. R., Elizah, P. N., Silvia, M., & Kurniyawan, E. H. (2024). Increased Incidence of Stunting Due to Pesticide Exposure in Agricultural Areas. Jurnal Bidan Mandiri, 2(2), 26-39. https://doi.org/10.33761/jbm.v2i2.1730

Rahmawati, A., Rahayu, H. S. E., & Rohmayanti. (2023). The Relationship between Pesticide Exposure in Pregnant Women and the Incidence of LBW at the Sawangan 1 Public Health Centre, Magelang Regency. Proceedings of the 3rd Borobudur International Symposium on Humanities and Social Science 2021 (BIS-HSS 2021), 40–46. https://doi.org/10.2991/978-2-494069-49-7_8

Shekhar, C., Khosya, R., Thakur, K., Mahajan, D., Kumar, R., Kumar, S., & Sharma, A. K. (2024). A systematic review of pesticide exposure, associated risks, and long-term human health impacts. Toxicology Reports, 13(November), 101840. https://doi.org/10.1016/j.toxrep.2024.101840

Simões, M., Vermeulen, R., Portengen, L., Janssen, N., & Huss, A. (2023). Exploring associations between residential exposure to pesticides and birth outcomes using the Dutch birth registry. Environment International, 178(July). https://doi.org/10.1016/j.envint.2023.108085

Suwannakul, B., Sapbamrer, R., Wiwattanadittakul, N., & Hongsibsong, S. (2021). Prenatal organophosphate exposure can cause adverse birth outcomes to humans. Environmental Science and Pollution Research, 28(33), 45064–45074. https://doi.org/10.1007/s11356-021-13974-8

Thapa, P., Poudyal, A., Poudel, R., Upadhyaya, D. P., Timalsina, A., Bhandari, R., Baral, J., Bhandari, R., Joshi, P. C., Thapa, P., & Adhikari, N. (2022). Prevalence of low birth weight and its associated factors: Hospital based cross sectional study in Nepal. PLOS Global Public Health, 2(11 November), 1–11. https://doi.org/10.1371/journal.pgph.0001220

van den Dries, M. A., Keil, A. P., Tiemeier, H., Pronk, A., Spaan, S., Santos, S., Asimakopoulos, A. G., Kannan, K., Gaillard, R., Guxens, M., Trasande, L., Jaddoe, V. W. V., & Ferguson, K. K. (2021). Prenatal exposure to nonpersistent chemical mixtures and fetal growth: A population-based study. Environmental Health Perspectives, 129(11), 1–13. https://doi.org/10.1289/EHP9178

Wylie, B., Kaali, S., & Duttweiler, L. (2025). Evaluation of gestational nonpersistent pesticide exposure with newborn size and gestational length in rural Ghana using a novel time-varying extension of multiple informant models. Environment International, 196(June 2024), 109292. https://doi.org/10.1016/j.envint.2025.109292

Yang, C., Fang, J., Sun, X., Zhang, W., Li, J., Chen, X., Yu, L., Xia, W., Xu, S., Cai, Z., & Li, Y. (2021). Prenatal exposure to organochlorine pesticides and infant growth: A longitudinal study. Environment International, 148, 106374. https://doi.org/10.1016/j.envint.2020.106374

Downloads

Published

2025-12-01